Helped a client this morning where the integration between Microsoft Outlook and ACT! kept being lost. I would fix it and it would work that day, then drop the next day. VERY frustrating for both client and I.
With the help of this ACT! KB article: ACT! icons & tabs not appearing in Outlook, we overcame part 1 of the issue, and then with a little scripting I've setup that workstation to keep a known good copy of the ACT! preferences and use that to overwrite the current preferences on each start-up of the workstation - that solved part 2 of the issue.
The ACT! preferences are kept in %appdata%\ACT\Act for Windows\
directory.
Another possible solution is found here: Preference Settings for Word Processor, E-mail, and Customization is Not Retained after Restarting Your Computer - although not helpful for time for me.